Neurology behind the Subluxation

Scientific Explanation of a Subluxation & How it leads to the Stress Response

1. When you lose the instantaneous axis of rotation of a vertebra due to a subluxation, you get the breakdown of glycosaminoglycans of the disc and other connective tissues which break down into polypeptides.
2. These polypeptides then stimulate the primary neuron of the nocioceptive system to fire on the second order neuron of the anterolateral system of the spinal cord. 
3. The second order neuron of the anterolateral system rises rostrally to the reticular formation and thalamus and then on to higher centers of the cortex for localization and interpretation of the pain.  

 3 Effects of Immobilization/Fixation of a Joint

Joints-            Increase in periarticular fibrosis, compressive loading, and rate of glycosaminoglycans synthesis.

Bone-             Decrease bone density, eburnation, bone spurs

Ligaments-  Decreased oxygen, glucose, sulfate, and increased lactate concentration

Muscle-         Decreased muscle mass, Type 1 & 2 muscle atrophy, increased connective tissue fibrosis.